Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition

Mice with deletion of Cyp2c70 have a human-like bile acid composition, display age- and sex-dependent signs of hepatobiliary disease and can be used as a model to study interactions between bile acids and the gut microbiota in cholestatic liver disease. In the present study, we rederived Cyp2c70(−/−...

Descripción completa

Detalles Bibliográficos
Autores principales: Sjöland, Wilhelm, Wahlström, Annika, Makki, Kassem, Schöler, Marc, Molinaro, Antonio, Olsson, Lisa, Greiner, Thomas Uwe, Caesar, Robert, de Boer, Jan Freark, Kuipers, Folkert, Bäckhed, Fredrik, Marschall, Hanns-Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Gastrointestinal, Renal & Hepatic Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346113/
https://www.ncbi.nlm.nih.gov/pubmed/37384590
http://dx.doi.org/10.1042/CS20230413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346113/
https://www.ncbi.nlm.nih.gov/pubmed/37384590
http://dx.doi.org/10.1042/CS20230413

Ejemplares similares