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Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition

Mice with deletion of Cyp2c70 have a human-like bile acid composition, display age- and sex-dependent signs of hepatobiliary disease and can be used as a model to study interactions between bile acids and the gut microbiota in cholestatic liver disease. In the present study, we rederived Cyp2c70(−/−...

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Detalles Bibliográficos
Autores principales:	Sjöland, Wilhelm, Wahlström, Annika, Makki, Kassem, Schöler, Marc, Molinaro, Antonio, Olsson, Lisa, Greiner, Thomas Uwe, Caesar, Robert, de Boer, Jan Freark, Kuipers, Folkert, Bäckhed, Fredrik, Marschall, Hanns-Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2023
Materias:	Gastrointestinal, Renal & Hepatic Systems
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10346113/ https://www.ncbi.nlm.nih.gov/pubmed/37384590 http://dx.doi.org/10.1042/CS20230413

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