Two-Sample Mendelian Randomization detects bidirectional causality between gut microbiota and celiac disease in individuals with high genetic risk

BACKGROUND: Celiac Disease (CeD) is an autoimmune disorder triggered by gluten intake in genetically susceptible individuals. Highest risk individuals are homozygous for the Human Leucocyte Antigen (HLA) DQ2.5 haplotype or DQ2.5/DQ2.2 heterozygous. Both the HLA-DQ2-positive high genetic risk individ...

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Detalles Bibliográficos
Autores principales: González-García, Bárbara P., Marí, Sergi, Cilleros-Portet, Ariadna, Hernangomez-Laderas, Alba, Fernandez-Jimenez, Nora, García-Santisteban, Iraia, Bilbao, Jose Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347381/
https://www.ncbi.nlm.nih.gov/pubmed/37457693
http://dx.doi.org/10.3389/fimmu.2023.1082862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347381/
https://www.ncbi.nlm.nih.gov/pubmed/37457693
http://dx.doi.org/10.3389/fimmu.2023.1082862

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