Targeting the Alternative Vitamin E Metabolite Binding Site Enables Noncanonical PPARγ Modulation

[Image: see text] The lipid-sensing transcription factor PPARγ is the target of antidiabetic thiazolidinediones (TZD). At two sites within its ligand binding domain, it also binds oxidized vitamin E metabolites and the vitamin E mimetic garcinoic acid. While the canonical interaction within the TZD...

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Detalles Bibliográficos
Autores principales: Arifi, Silvia, Marschner, Julian A., Pollinger, Julius, Isigkeit, Laura, Heitel, Pascal, Kaiser, Astrid, Obeser, Lennart, Höfner, Georg, Proschak, Ewgenij, Knapp, Stefan, Chaikuad, Apirat, Heering, Jan, Merk, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347545/
https://www.ncbi.nlm.nih.gov/pubmed/37385602
http://dx.doi.org/10.1021/jacs.3c03417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347545/
https://www.ncbi.nlm.nih.gov/pubmed/37385602
http://dx.doi.org/10.1021/jacs.3c03417

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