Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Phototherapeutic Prodrugs for the Treatment of Brain Tumors

[Image: see text] To investigate the potential of tumor-targeting photoactivated chemotherapy, a chiral ruthenium-based anticancer warhead, Λ/Δ-[Ru(Ph(2)phen)(2)(OH(2))(2)](2+), was conjugated to the RGD-containing Ac-MRGDH-NH(2) peptide by direct coordination of the M and H residues to the metal. T...

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Detalles Bibliográficos
Autores principales: Zhang, Liyan, Wang, Peiyuan, Zhou, Xue-Quan, Bretin, Ludovic, Zeng, Xiaolong, Husiev, Yurii, Polanco, Ehider A., Zhao, Gangyin, Wijaya, Lukas S., Biver, Tarita, Le Dévédec, Sylvia E., Sun, Wen, Bonnet, Sylvestre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347550/
https://www.ncbi.nlm.nih.gov/pubmed/37379365
http://dx.doi.org/10.1021/jacs.3c04855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347550/
https://www.ncbi.nlm.nih.gov/pubmed/37379365
http://dx.doi.org/10.1021/jacs.3c04855

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