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Cyclic Ruthenium-Peptide Conjugates as Integrin-Targeting Phototherapeutic Prodrugs for the Treatment of Brain Tumors
[Image: see text] To investigate the potential of tumor-targeting photoactivated chemotherapy, a chiral ruthenium-based anticancer warhead, Λ/Δ-[Ru(Ph(2)phen)(2)(OH(2))(2)](2+), was conjugated to the RGD-containing Ac-MRGDH-NH(2) peptide by direct coordination of the M and H residues to the metal. T...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347550/ https://www.ncbi.nlm.nih.gov/pubmed/37379365 http://dx.doi.org/10.1021/jacs.3c04855 |