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Increased prime edit rates in KCNQ2 and SCN1A via single nicking all-in-one plasmids
BACKGROUND: Prime editing (PE) is the most recent gene editing technology able to introduce targeted alterations to the genome, including single base pair changes, small insertions, and deletions. Several improvements to the PE machinery have been made in the past few years, and these have been test...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347817/ https://www.ncbi.nlm.nih.gov/pubmed/37443005 http://dx.doi.org/10.1186/s12915-023-01646-7 |