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Identification of residues critical for the extension of Munc18-1 domain 3a

BACKGROUND: Neurotransmitter release depends on the fusion of synaptic vesicles with the presynaptic membrane and is mainly mediated by SNARE complex assembly. During the transition of Munc18-1/Syntaxin-1 to the SNARE complex, the opening of the Syntaxin-1 linker region catalyzed by Munc13-1 leads t...

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Detalles Bibliográficos
Autores principales: Wang, Xianping, Gong, Jihong, Zhu, Le, Chen, Huidan, Jin, Ziqi, Mo, Xiaoqiang, Wang, Shen, Yang, Xiaofei, Ma, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10347870/
https://www.ncbi.nlm.nih.gov/pubmed/37443000
http://dx.doi.org/10.1186/s12915-023-01655-6