RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy

RIT1 is a RAS guanosine triphosphatase (GTPase) that regulates different aspects of signal transduction and is mutated in lung cancer, leukemia, and in the germline of individuals with Noonan syndrome. Pathogenic RIT1 proteins promote mitogen-activated protein kinase (MAPK) hyperactivation; however,...

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Detalles Bibliográficos
Autores principales: Cuevas-Navarro, Antonio, Wagner, Morgan, Van, Richard, Swain, Monalisa, Mo, Stephanie, Columbus, John, Allison, Madeline R., Cheng, Alice, Messing, Simon, Turbyville, Thomas J., Simanshu, Dhirendra K., Sale, Matthew J., McCormick, Frank, Stephen, Andrew G., Castel, Pau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348673/
https://www.ncbi.nlm.nih.gov/pubmed/37450595
http://dx.doi.org/10.1126/sciadv.adf4766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348673/
https://www.ncbi.nlm.nih.gov/pubmed/37450595
http://dx.doi.org/10.1126/sciadv.adf4766

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