Cargando…
Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase
G protein–coupled receptor (GPCR) signaling is precisely controlled to avoid overstimulation that results in detrimental consequences. Gβγ signaling is negatively regulated by a Cullin3 (Cul3)–dependent E3 ligase, KCTD5, which triggers ubiquitination and degradation of free Gβγ. Here, we report the...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348674/ https://www.ncbi.nlm.nih.gov/pubmed/37450587 http://dx.doi.org/10.1126/sciadv.adg8369 |