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Structural basis for the ubiquitination of G protein βγ subunits by KCTD5/Cullin3 E3 ligase

G protein–coupled receptor (GPCR) signaling is precisely controlled to avoid overstimulation that results in detrimental consequences. Gβγ signaling is negatively regulated by a Cullin3 (Cul3)–dependent E3 ligase, KCTD5, which triggers ubiquitination and degradation of free Gβγ. Here, we report the...

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Detalles Bibliográficos
Autores principales:	Jiang, Wentong, Wang, Wei, Kong, Yinfei, Zheng, Sanduo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348674/ https://www.ncbi.nlm.nih.gov/pubmed/37450587 http://dx.doi.org/10.1126/sciadv.adg8369

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