Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells

The genetic circuits that allow cancer cells to evade immune killing via epithelial mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like (Mes) KPC3 pancreatic cancer cells were more resistant to cytotoxic T lymphocyte (CTL)–mediated killing than the parental epithel...

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Detalles Bibliográficos
Autores principales: Gu, Yuanzhuo, Zhang, Zhengkui, Camps, Marcel G. M., Ossendorp, Ferry, Wijdeven, Ruud H., ten Dijke, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348683/
https://www.ncbi.nlm.nih.gov/pubmed/37450593
http://dx.doi.org/10.1126/sciadv.adf9915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348683/
https://www.ncbi.nlm.nih.gov/pubmed/37450593
http://dx.doi.org/10.1126/sciadv.adf9915

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