Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality

Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding of how rejection occurs despite immunosuppression (IS). We performed combined single-cell RNA transc...

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Detalles Bibliográficos
Autores principales: Shi, Tiffany, Burg, Ashley R., Caldwell, J. Timothy, Roskin, Krishna M., Castro-Rojas, Cyd M., Chukwuma, P. Chukwunalu, Gray, George I., Foote, Sara G., Alonso, Jesus A., Cuda, Carla M., Allman, David A., Rush, James S., Regnier, Catherine H., Wieczorek, Grazyna, Alloway, Rita R., Shields, Adele R., Baker, Brian M., Woodle, E. Steve, Hildeman, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348771/
https://www.ncbi.nlm.nih.gov/pubmed/37227784
http://dx.doi.org/10.1172/JCI170191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348771/
https://www.ncbi.nlm.nih.gov/pubmed/37227784
http://dx.doi.org/10.1172/JCI170191

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