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Inhibition of DPAGT1 suppresses HER2 shedding and trastuzumab resistance in human breast cancer
Human epidermal growth factor receptor 2–targeted (HER2-targeted) therapy is the mainstay of treatment for HER2(+) breast cancer. However, the proteolytic cleavage of HER2, or HER2 shedding, induces the release of the target epitope at the ectodomain (ECD) and the generation of a constitutively acti...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348774/ https://www.ncbi.nlm.nih.gov/pubmed/37463446 http://dx.doi.org/10.1172/JCI164428 |