Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor

Hormone receptor-positive, HER2-negative advanced breast cancers exhibit high sensitivity to CDK4/6 inhibitors such as palbociclib. However, most patients inevitably develop resistance, thus identification of new actionable therapeutic targets to overcome the recurrent disease is an urgent need. Imm...

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Detalles Bibliográficos
Autores principales: Sawant, Mithila, Wilson, Audrey, Sridaran, Dhivya, Mahajan, Kiran, O’Conor, Christopher J., Hagemann, Ian S., Luo, Jingqin, Weimholt, Cody, Li, Tiandao, Roa, Juan Carlos, Pandey, Akhilesh, Wu, Xinyan, Mahajan, Nupam P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348910/
https://www.ncbi.nlm.nih.gov/pubmed/37330596
http://dx.doi.org/10.1038/s41388-023-02747-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348910/
https://www.ncbi.nlm.nih.gov/pubmed/37330596
http://dx.doi.org/10.1038/s41388-023-02747-x

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