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Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions

Depressive symptoms in Parkinson’s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. Here, we compared the prevalence and severity of depressive sym...

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Autores principales: Usnich, Tatiana, Hauptmann, Björn, Hanssen, Henrike, Prasuhn, Jannik, Balck, Alexander, Borsche, Max, Tadic, Vera, Klee, Annika, Noblejas-Sanchez, Greta, Vollstedt, Eva-Juliane, Klein, Christine, Brüggemann, Norbert, Kasten, Meike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349053/
https://www.ncbi.nlm.nih.gov/pubmed/37452071
http://dx.doi.org/10.1038/s41531-023-00551-8
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author Usnich, Tatiana
Hauptmann, Björn
Hanssen, Henrike
Prasuhn, Jannik
Balck, Alexander
Borsche, Max
Tadic, Vera
Klee, Annika
Noblejas-Sanchez, Greta
Vollstedt, Eva-Juliane
Klein, Christine
Brüggemann, Norbert
Kasten, Meike
author_facet Usnich, Tatiana
Hauptmann, Björn
Hanssen, Henrike
Prasuhn, Jannik
Balck, Alexander
Borsche, Max
Tadic, Vera
Klee, Annika
Noblejas-Sanchez, Greta
Vollstedt, Eva-Juliane
Klein, Christine
Brüggemann, Norbert
Kasten, Meike
author_sort Usnich, Tatiana
collection PubMed
description Depressive symptoms in Parkinson’s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. Here, we compared the prevalence and severity of depressive symptoms in PD patients and disease controls (DC). PD patients reported depressive symptoms at similar frequencies as DC but were on antidepressants, especially Mirtazapine, more frequently. Still, in both groups, a high proportion of patients with clinically significant depressive symptoms was not receiving medication. Diagnosis and treatment of depressive symptoms both in PD and DC should be improved.
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spelling pubmed-103490532023-07-16 Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions Usnich, Tatiana Hauptmann, Björn Hanssen, Henrike Prasuhn, Jannik Balck, Alexander Borsche, Max Tadic, Vera Klee, Annika Noblejas-Sanchez, Greta Vollstedt, Eva-Juliane Klein, Christine Brüggemann, Norbert Kasten, Meike NPJ Parkinsons Dis Brief Communication Depressive symptoms in Parkinson’s disease (PD) are multifactorial and are partly linked to the underlying dopaminergic deficit. However, at least a subset of PD patients may exhibit an unspecific depressive reaction to chronic illness. Here, we compared the prevalence and severity of depressive symptoms in PD patients and disease controls (DC). PD patients reported depressive symptoms at similar frequencies as DC but were on antidepressants, especially Mirtazapine, more frequently. Still, in both groups, a high proportion of patients with clinically significant depressive symptoms was not receiving medication. Diagnosis and treatment of depressive symptoms both in PD and DC should be improved. Nature Publishing Group UK 2023-07-14 /pmc/articles/PMC10349053/ /pubmed/37452071 http://dx.doi.org/10.1038/s41531-023-00551-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Usnich, Tatiana
Hauptmann, Björn
Hanssen, Henrike
Prasuhn, Jannik
Balck, Alexander
Borsche, Max
Tadic, Vera
Klee, Annika
Noblejas-Sanchez, Greta
Vollstedt, Eva-Juliane
Klein, Christine
Brüggemann, Norbert
Kasten, Meike
Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions
title Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions
title_full Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions
title_fullStr Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions
title_full_unstemmed Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions
title_short Depressive symptoms in Parkinson’s disease are insufficiently but more often treated than in other chronic conditions
title_sort depressive symptoms in parkinson’s disease are insufficiently but more often treated than in other chronic conditions
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349053/
https://www.ncbi.nlm.nih.gov/pubmed/37452071
http://dx.doi.org/10.1038/s41531-023-00551-8
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