Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis. Here we report that defective cystine mobilization from lysosomes t...

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Detalles Bibliográficos
Autores principales: Berquez, Marine, Chen, Zhiyong, Festa, Beatrice Paola, Krohn, Patrick, Keller, Svenja Aline, Parolo, Silvia, Korzinkin, Mikhail, Gaponova, Anna, Laczko, Endre, Domenici, Enrico, Devuyst, Olivier, Luciani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349091/
https://www.ncbi.nlm.nih.gov/pubmed/37452023
http://dx.doi.org/10.1038/s41467-023-39261-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349091/
https://www.ncbi.nlm.nih.gov/pubmed/37452023
http://dx.doi.org/10.1038/s41467-023-39261-3

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