SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling

The spike protein of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) can interact with endothelial cells. However, no studies demonstrated the direct effect of the spike protein subunit 1 (S1) in inducing lung vascular damage and the potential mechanisms contributing to lung injury. Her...

Descripción completa

Detalles Bibliográficos
Autores principales: Perico, Luca, Morigi, Marina, Pezzotta, Anna, Locatelli, Monica, Imberti, Barbara, Corna, Daniela, Cerullo, Domenico, Benigni, Ariela, Remuzzi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349115/
https://www.ncbi.nlm.nih.gov/pubmed/37452090
http://dx.doi.org/10.1038/s41598-023-38382-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349115/
https://www.ncbi.nlm.nih.gov/pubmed/37452090
http://dx.doi.org/10.1038/s41598-023-38382-5

Ejemplares similares