In vaccinated individuals serum bactericidal activity against B meningococci is abrogated by C5 inhibition but not by inhibition of the alternative complement pathway

INTRODUCTION: Several diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3. However, complement is required for serum bactericidal activity (SBA) against encapsulated Gram-negative bacteria. Therefore, C3 and C5 inhibi...

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Detalles Bibliográficos
Autores principales: Ispasanie, Emma, Muri, Lukas, Schmid, Marc, Schubart, Anna, Thorburn, Christine, Zamurovic, Natasa, Holbro, Thomas, Kammüller, Michael, Pluschke, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349132/
https://www.ncbi.nlm.nih.gov/pubmed/37457736
http://dx.doi.org/10.3389/fimmu.2023.1180833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349132/
https://www.ncbi.nlm.nih.gov/pubmed/37457736
http://dx.doi.org/10.3389/fimmu.2023.1180833

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