Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity

Hemophilia A is the most common X-linked bleeding disorder affecting more than half-a-million individuals worldwide. Persons with severe hemophilia A have coagulation FVIII levels <1% and experience spontaneous debilitating and life-threatening bleeds. Advances in hemophilia A therapeutics have s...

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Detalles Bibliográficos
Autores principales: Rodriguez, Martin, Trevisan, Brady, Ramamurthy, Ritu M., George, Sunil K., Diaz, Jonathan, Alexander, Jordan, Meares, Diane, Schwahn, Denise J., Quilici, David R., Figueroa, Jorge, Gautreaux, Michael, Farland, Andrew, Atala, Anthony, Doering, Christopher B., Spencer, H. Trent, Porada, Christopher D., Almeida-Porada, Graça
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349136/
https://www.ncbi.nlm.nih.gov/pubmed/37452013
http://dx.doi.org/10.1038/s41467-023-39986-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349136/
https://www.ncbi.nlm.nih.gov/pubmed/37452013
http://dx.doi.org/10.1038/s41467-023-39986-1

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