Cargando…

Molecular dissection and testing of PRSS37 function through LC–MS/MS and the generation of a PRSS37 humanized mouse model

The quest for a non-hormonal male contraceptive pill for men still exists. Serine protease 37 (PRSS37) is a sperm-specific protein that when ablated in mice renders them sterile. In this study we sought to examine the molecular sequelae of PRSS37 loss to better understand its molecular function, and...

Descripción completa

Detalles Bibliográficos
Autores principales: Sutton, Courtney, Nozawa, Kaori, Kent, Katarzyna, Saltzman, Alexander, Leng, Mei, Nagarajan, Sureshbabu, Malovannaya, Anna, Ikawa, Masahito, Garcia, Thomas X., Matzuk, Martin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349139/
https://www.ncbi.nlm.nih.gov/pubmed/37452050
http://dx.doi.org/10.1038/s41598-023-37700-1