Minimal mechanistic component of HbYX-dependent proteasome activation that reverses impairment by neurodegenerative-associated oligomers

The implication of reduced proteasomal function in neurodegenerative diseases combined with studies showing the protective effects of increasing proteasome activity in animal models highlight the need to understand the capacity for proteasome activation by small molecules. The C-terminal HbYX motif...

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Detalles Bibliográficos
Autores principales: Chuah, Janelle J. Y., Thibaudeau, Tiffany A., Smith, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349142/
https://www.ncbi.nlm.nih.gov/pubmed/37452144
http://dx.doi.org/10.1038/s42003-023-05082-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349142/
https://www.ncbi.nlm.nih.gov/pubmed/37452144
http://dx.doi.org/10.1038/s42003-023-05082-9

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