SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice and cultured pulmonary vascular endothelial cells...

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Detalles Bibliográficos
Autores principales: Yang, Kai, Liu, Shiyun, Yan, Han, Lu, Wenju, Shan, Xiaoqian, Chen, Haixia, Bao, Changlei, Feng, Huazhuo, Liao, Jing, Liang, Shuxin, Xu, Lei, Tang, Haiyang, Yuan, Jason X.-J., Zhong, Nanshan, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349149/
https://www.ncbi.nlm.nih.gov/pubmed/37452066
http://dx.doi.org/10.1038/s41392-023-01556-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349149/
https://www.ncbi.nlm.nih.gov/pubmed/37452066
http://dx.doi.org/10.1038/s41392-023-01556-8

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