Cargando…

SARS-CoV-2 spike protein receptor-binding domain perturbates intracellular calcium homeostasis and impairs pulmonary vascular endothelial cells

Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy. In this study, angiotensin-converting enzyme 2 humanized inbred (hACE2 Tg) mice and cultured pulmonary vascular endothelial cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Kai, Liu, Shiyun, Yan, Han, Lu, Wenju, Shan, Xiaoqian, Chen, Haixia, Bao, Changlei, Feng, Huazhuo, Liao, Jing, Liang, Shuxin, Xu, Lei, Tang, Haiyang, Yuan, Jason X.-J., Zhong, Nanshan, Wang, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349149/ https://www.ncbi.nlm.nih.gov/pubmed/37452066 http://dx.doi.org/10.1038/s41392-023-01556-8

Ejemplares similares

FAD Mutations in Amyloid Precursor Protein Do Not Directly Perturb Intracellular Calcium Homeostasis
por: Stieren, Emily, et al.
Publicado: (2010)

Extracellular and Intracellular Regulation of Calcium Homeostasis
por: Bronner, Felix
Publicado: (2001)

Mitochondrial Metabolism, Redox, and Calcium Homeostasis in Pulmonary Arterial Hypertension
por: Liang, Shuxin, et al.
Publicado: (2022)

Sevoflurane modulates breast cancer cell survival via modulation of intracellular calcium homeostasis
por: Deng, Xiaoqian, et al.
Publicado: (2020)

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
por: Liang, Shuxin, et al.
Publicado: (2023)

Perturbation of Intracellular Cholesterol and Fatty Acid Homeostasis During Flavivirus Infections
por: Pombo, Joao Palma, et al.
Publicado: (2018)

Altered Intracellular Calcium Homeostasis and Arrhythmogenesis in the Aged Heart
por: Hamilton, Shanna, et al.
Publicado: (2019)

Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer’s Disease
por: Huang, Dong-Xu, et al.
Publicado: (2022)

Perturbation of calcium homeostasis by CCl4 in rats pretreated with chlordecone and phenobarbital.
por: Agarwal, A K, et al.
Publicado: (1984)

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells
por: Zou, Zijiao, et al.
Publicado: (2020)

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells
por: Yan, Bingpeng, et al.
Publicado: (2019)

Intracellular Calcium Spikes in Rat Suprachiasmatic Nucleus Neurons Induced by BAPTA-Based Calcium Dyes
por: Hong, Jin Hee, et al.
Publicado: (2010)

Intracellular Staphylococcus aureus Perturbs the Host Cell Ca(2+) Homeostasis To Promote Cell Death
por: Stelzner, Kathrin, et al.
Publicado: (2020)

Ginkgolide B Maintains Calcium Homeostasis in Hypoxic Hippocampal Neurons by Inhibiting Calcium Influx and Intracellular Calcium Release
por: Wang, Li, et al.
Publicado: (2021)

TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis
por: Shambharkar, Prashant B., et al.
Publicado: (2015)

TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells
por: Arhatte, Malika, et al.
Publicado: (2019)

Disruption of Intracellular Calcium Homeostasis as a Therapeutic Target Against Trypanosoma cruzi
por: Benaim, Gustavo, et al.
Publicado: (2020)

Diabetes Alters Intracellular Calcium Transients in Cardiac Endothelial Cells
por: Sheikh, Abdul Q., et al.
Publicado: (2012)

Selective vulnerability of motoneuron and perturbed mitochondrial calcium homeostasis in amyotrophic lateral sclerosis: implications for motoneurons specific calcium dysregulation
por: Jaiswal, Manoj Kumar
Publicado: (2014)

Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator
Publicado: (1982)

Calcineurin-mediated intracellular organelle calcium homeostasis is required for the survival of fungal pathogens upon extracellular calcium stimuli
por: Zhang, Chi, et al.
Publicado: (2021)

Perturbation of ubiquitin homeostasis promotes macrophage oxidative defenses
por: Charbonneau, Marie-Eve, et al.
Publicado: (2019)

The Role of TRP Channels and PMCA in Brain Disorders: Intracellular Calcium and pH Homeostasis
por: Hwang, Sung-Min, et al.
Publicado: (2021)

Salusin-β, a TOR2A gene product, promotes proliferation, migration, fibrosis, and calcification of smooth muscle cells and accelerates the imbalance of vasomotor function and vascular remodeling in monocrotaline-induced pulmonary hypertensive rats
por: Wang, Xingxing, et al.
Publicado: (2022)

Shikonin causes apoptosis by disrupting intracellular calcium homeostasis and mitochondrial function in human hepatoma cells
por: Wang, Hui, et al.
Publicado: (2018)

Role of Calcium/Calcineurin Signalling in Regulating Intracellular Reactive Oxygen Species Homeostasis in Saccharomyces cerevisiae
por: Li, Guohui, et al.
Publicado: (2021)

Release of Intracellular Calcium Stores Facilitates Coxsackievirus Entry into Polarized Endothelial Cells
por: Bozym, Rebecca A., et al.
Publicado: (2010)

Effects of chlorogenic acid on intracellular calcium regulation in lysophosphatidylcholine-treated endothelial cells
por: Jung, Hye-Jin, et al.
Publicado: (2017)

Amyotrophic lateral sclerosis-associated mutant VAPBP56S perturbs calcium homeostasis to disrupt axonal transport of mitochondria
por: Mórotz, Gábor M., et al.
Publicado: (2012)

Reversing ferroptosis resistance by MOFs through regulation intracellular redox homeostasis
por: Wang, Chengcheng, et al.
Publicado: (2023)

Role of Phytochemicals in Perturbation of Redox Homeostasis in Cancer
por: Gaikwad, Shreyas, et al.
Publicado: (2021)

Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis
por: Sterlin, Delphine, et al.
Publicado: (2021)

ER stress increases expression of intracellular calcium channel RyR1 to modify Ca(2+) homeostasis in pancreatic beta cells
por: Zhang, Irina X., et al.
Publicado: (2023)

Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of intracellular calcium homeostasis
por: Zhang, Li, et al.
Publicado: (2018)

Neurotoxic Effects of Platinum Compounds: Studies in vivo on Intracellular Calcium Homeostasis in the Immature Central Nervous System
por: Bernocchi, Graziella, et al.
Publicado: (2015)

Liraglutide directly protects cardiomyocytes against reperfusion injury possibly via modulation of intracellular calcium homeostasis
por: Hu, Shun-Ying, et al.
Publicado: (2017)

FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics
por: Yin, Yujing, et al.
Publicado: (2022)

Crystallization and Structural Determination of the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
por: Zhou, Haixia, et al.
Publicado: (2019)

Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium
Publicado: (1993)

The influence of statins on the free intracellular calcium concentration in human umbilical vein endothelial cells
por: Heinke, Stephan, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_h6qtgn0ri1skc4iu8imjmlqc60