Our current understanding of the toxicity of altered mito-ribosomal fidelity during mitochondrial protein synthesis: What can it tell us about human disease?

Altered mito-ribosomal fidelity is an important and insufficiently understood causative agent of mitochondrial dysfunction. Its pathogenic effects are particularly well-known in the case of mitochondrially induced deafness, due to the existence of the, so called, ototoxic variants at positions 847C...

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Detalles Bibliográficos
Autores principales: Vila-Sanjurjo, Antón, Mallo, Natalia, Atkins, John F., Elson, Joanna L., Smith, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349377/
https://www.ncbi.nlm.nih.gov/pubmed/37457031
http://dx.doi.org/10.3389/fphys.2023.1082953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349377/
https://www.ncbi.nlm.nih.gov/pubmed/37457031
http://dx.doi.org/10.3389/fphys.2023.1082953

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