Dysfunctional neuro-muscular mechanisms explain gradual gait changes in prodromal spastic paraplegia

BACKGROUND: In Hereditary Spastic Paraplegia (HSP) type 4 (SPG4) a length-dependent axonal degeneration in the cortico-spinal tract leads to progressing symptoms of hyperreflexia, muscle weakness, and spasticity of lower extremities. Even before the manifestation of spastic gait, in the prodromal ph...

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Detalles Bibliográficos
Autores principales: Lassmann, Christian, Ilg, Winfried, Rattay, Tim W., Schöls, Ludger, Giese, Martin, Haeufle, Daniel F. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349428/
https://www.ncbi.nlm.nih.gov/pubmed/37454121
http://dx.doi.org/10.1186/s12984-023-01206-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349428/
https://www.ncbi.nlm.nih.gov/pubmed/37454121
http://dx.doi.org/10.1186/s12984-023-01206-8

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