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Icariin promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells in patients with osteoporosis and T2DM by upregulating GLI-1

BACKGROUND: The function of mesenchymal stem cells (MSCs) from patients with osteoporosis (OP) is impaired and worsens in patients with type 2 diabetes mellitus (T2DM). Icariin (ICA) is the major active flavonoid glucoside isolated from traditional Chinese herbal Epimedium pubescens, and confirmed a...

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Detalles Bibliográficos
Autores principales: Xia, Sheng-li, Ma, Zi-yuan, Wang, Bin, Gao, Feng, Guo, Sheng-yang, Chen, Xu-han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349431/
https://www.ncbi.nlm.nih.gov/pubmed/37454090
http://dx.doi.org/10.1186/s13018-023-03998-w