Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice

BACKGROUND: Genome-wide association studies (GWAS) have reported single-nucleotide polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome-wide significant associations with major depression, but the regulation effect of the risk SNPs on VRK2 as well as their roles in th...

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Detalles Bibliográficos
Autores principales: Yin, Mei-Yu, Guo, Lei, Zhao, Li-Juan, Zhang, Chen, Liu, Wei-Peng, Zhang, Chu-Yi, Huo, Jin-Hua, Wang, Lu, Li, Shi-Wu, Zheng, Chang-Bo, Xiao, Xiao, Li, Ming, Wang, Chuang, Chang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349461/
https://www.ncbi.nlm.nih.gov/pubmed/37452335
http://dx.doi.org/10.1186/s12916-023-02945-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349461/
https://www.ncbi.nlm.nih.gov/pubmed/37452335
http://dx.doi.org/10.1186/s12916-023-02945-0

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