HDAC inhibition delays photoreceptor loss in Pde6b mutant mice of retinitis pigmentosa: insights from scRNA-seq and CUT&Tag

PURPOSE: This research aimed to ascertain the neuroprotective effect of histone deacetylase (HDAC) inhibition on retinal photoreceptors in Pde6b(rd1) mice, a model of retinitis pigmentosa (RP). METHODS: Single-cell RNA-sequencing (scRNA-seq) explored HDAC and poly (ADP-ribose) polymerase (PARP)-rela...

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Detalles Bibliográficos
Autores principales: Dong, Yujie, Yan, Jie, Xu, Wenrong, Paquet-Durand, François, Hu, Zhulin, Jiao, Kangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2023
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349563/
https://www.ncbi.nlm.nih.gov/pubmed/37456870
http://dx.doi.org/10.7717/peerj.15659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349563/
https://www.ncbi.nlm.nih.gov/pubmed/37456870
http://dx.doi.org/10.7717/peerj.15659

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