miR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia

Acute myeloid leukemia (AML) is a hematological malignancy characterized by the impaired differentiation and uncontrolled proliferation of myeloid blasts. Tumor suppressor p53 is often downregulated in AML cells via ubiquitination-mediated degradation. While the role of E3 ligase MDM2 in p53 ubiquit...

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Detalles Bibliográficos
Autores principales: Pei, Han Zhong, Peng, Zhiyong, Zhuang, Xiaomei, Wang, Xiaobo, Lu, Bo, Guo, Yao, Zhao, Yuming, Zhang, Dengyang, Xiao, Yunjun, Gao, Tianshun, Yu, Liuting, He, Chunxiao, Wu, Shunjie, Baek, Suk-Hwan, Zhao, Zhizhuang Joe, Xu, Xiaojun, Chen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349814/
https://www.ncbi.nlm.nih.gov/pubmed/37454155
http://dx.doi.org/10.1038/s41420-023-01537-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349814/
https://www.ncbi.nlm.nih.gov/pubmed/37454155
http://dx.doi.org/10.1038/s41420-023-01537-4

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