Advantages and potential limitations of applying AFM kymograph analysis to pharmaceutically relevant membrane proteins in lipid bilayers

Membrane proteins play critical roles in disease and in the disposition of many pharmaceuticals. A prime example is P-glycoprotein (Pgp) which moves a diverse range of drugs across membranes and out of the cell before a therapeutic payload can be delivered. Conventional structural biology methods ha...

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Detalles Bibliográficos
Autores principales: Schaefer, Katherine G., Roberts, Arthur G., King, Gavin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349840/
https://www.ncbi.nlm.nih.gov/pubmed/37454132
http://dx.doi.org/10.1038/s41598-023-37910-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349840/
https://www.ncbi.nlm.nih.gov/pubmed/37454132
http://dx.doi.org/10.1038/s41598-023-37910-7

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