Design of ion channel blocking, toxin-like Kunitz inhibitor peptides from the tapeworm, Echinococcus granulosus, with potential anti-cancer activity

Over-expression of K+ channels has been reported in human cancers and is associated with the poor prognosis of several malignancies. EAG1, a particular potassium ion channel, is widely expressed in the brain but poorly expressed in other normal tissues. Kunitz proteins are dominant in metazoan inclu...

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Detalles Bibliográficos
Autores principales: Rashno, Zahra, Rismani, Elham, Ghasemi, Jahan B., Mansouri, Mehdi, Shabani, Mohammad, Afgar, Ali, Dabiri, Shahriar, Rezaei Makhouri, Farahnaz, Hatami, Abbas, Harandi, Majid Fasihi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349847/
https://www.ncbi.nlm.nih.gov/pubmed/37454225
http://dx.doi.org/10.1038/s41598-023-38159-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349847/
https://www.ncbi.nlm.nih.gov/pubmed/37454225
http://dx.doi.org/10.1038/s41598-023-38159-w

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