Synthetic lethality in large-scale integrated metabolic and regulatory network models of human cells

Synthetic lethality (SL) is a promising concept in cancer research. A wide array of computational tools has been developed to predict and exploit synthetic lethality for the identification of tumour-specific vulnerabilities. Previously, we introduced the concept of genetic Minimal Cut Sets (gMCSs),...

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Detalles Bibliográficos
Autores principales: Barrena, Naroa, Valcárcel, Luis V., Olaverri-Mendizabal, Danel, Apaolaza, Iñigo, Planes, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349875/
https://www.ncbi.nlm.nih.gov/pubmed/37454223
http://dx.doi.org/10.1038/s41540-023-00296-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349875/
https://www.ncbi.nlm.nih.gov/pubmed/37454223
http://dx.doi.org/10.1038/s41540-023-00296-3

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