In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir

Ensitrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro or Nsp5), is clinically useful against SARS-CoV-2 including its omicron variants. Since most omicron subvariants have reduced sensitivity to most monoclonal antibody therapies, SARS-CoV-2 resistance to other antivir...

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Detalles Bibliográficos
Autores principales: Kiso, Maki, Yamayoshi, Seiya, Iida, Shun, Furusawa, Yuri, Hirata, Yuichiro, Uraki, Ryuta, Imai, Masaki, Suzuki, Tadaki, Kawaoka, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349878/
https://www.ncbi.nlm.nih.gov/pubmed/37454219
http://dx.doi.org/10.1038/s41467-023-40018-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349878/
https://www.ncbi.nlm.nih.gov/pubmed/37454219
http://dx.doi.org/10.1038/s41467-023-40018-1

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