LRRK2 phosphorylation status and kinase activity regulate (macro)autophagy in a Rab8a/Rab10-dependent manner

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson’s disease (PD), with growing importance also for Crohn’s disease and cancer. LRRK2 is a large and complex protein possessing both GTPase and kinase activity. Moreover, LRRK2 activity and functio...

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Detalles Bibliográficos
Autores principales: Kania, Elżbieta, Long, Jaclyn S., McEwan, David G., Welkenhuyzen, Kirsten, La Rovere, Rita, Luyten, Tomas, Halpin, John, Lobbestael, Evy, Baekelandt, Veerle, Bultynck, Geert, Ryan, Kevin M., Parys, Jan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349885/
https://www.ncbi.nlm.nih.gov/pubmed/37454104
http://dx.doi.org/10.1038/s41419-023-05964-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349885/
https://www.ncbi.nlm.nih.gov/pubmed/37454104
http://dx.doi.org/10.1038/s41419-023-05964-0

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