Deletion of VPS50 protein in mice brain impairs synaptic function and behavior

VPS50, is an accessory protein, involved in the synaptic and dense core vesicle acidification and its alterations produce behavioral changes in C.elegans. Here, we produce the mosaic knock out (mKO) of VPS50 using CRISPR/Cas9 system in both cortical cultured neurons and whole animals to evaluate the...

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Detalles Bibliográficos
Autores principales: Ahumada-Marchant, Constanza, Ancatén-Gonzalez, Carlos, Haensgen, Henny, Arancibia, Felipe, Brauer, Bastian, Droste, Rita, Horvitz, H. Robert, Constantine-Paton, Martha, Arriagada, Gloria, Chávez, Andrés E, Bustos, Fernando J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349947/
https://www.ncbi.nlm.nih.gov/pubmed/37461727
http://dx.doi.org/10.1101/2023.07.04.547745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349947/
https://www.ncbi.nlm.nih.gov/pubmed/37461727
http://dx.doi.org/10.1101/2023.07.04.547745

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