Inactivation of phosphodiesterase-4B gene in rat nucleus accumbens shell by CRISPR/Cas9 modulates the motivation to chronically self-administer nicotine

Large scale human genome wide association studies (GWAS) have identified a growing pool of genes associated with cigarette smoking. One of the most prominent, phosphodiesterase-4B (PDE4B), has been associated with multiple smoking phenotypes. Although PDE4B modulates the half-life of neuronal cAMP,...

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Detalles Bibliográficos
Autores principales: Sharp, Burt M, Jiang, Qin, Kim, Panjun, Chen, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349965/
https://www.ncbi.nlm.nih.gov/pubmed/37461457
http://dx.doi.org/10.1101/2023.03.07.531588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10349965/
https://www.ncbi.nlm.nih.gov/pubmed/37461457
http://dx.doi.org/10.1101/2023.03.07.531588

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