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Double and triple thermodynamic mutant cycles reveal the basis for specific MsbA-lipid interactions

Structural and functional studies of the ATP-binding cassette transporter MsbA have revealed two distinct lipopolysaccharide (LPS) binding sites: one located in the central cavity and the other at a membrane-facing, exterior site. Although these binding sites are known to be important for MsbA funct...

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Detalles Bibliográficos
Autores principales: Lyu, Jixing, Zhang, Tianqi, Marty, Michael T., Clemmer, David, Russell, David H., Laganowsky, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350010/
https://www.ncbi.nlm.nih.gov/pubmed/37461710
http://dx.doi.org/10.1101/2023.07.03.547565