On-Pathway Oligomer of Human Islet Amyloid Polypeptide Induced and Stabilized by Mechanical Rotation During MAS NMR

Intermediates along the fibrillation pathway are generally considered to be the toxic species responsible for the pathologies of amyloid diseases. However, structural studies of these species have been hampered by heterogeneity and poor stability in standard aqueous conditions. Here, we report a nov...

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Detalles Bibliográficos
Autores principales: McCalpin, Samuel D., Widanage, Malitha C. Dickwella, Fu, Riqiang, Ramamoorthy, Ayyalusamy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350039/
https://www.ncbi.nlm.nih.gov/pubmed/37461639
http://dx.doi.org/10.1101/2023.07.06.547982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350039/
https://www.ncbi.nlm.nih.gov/pubmed/37461639
http://dx.doi.org/10.1101/2023.07.06.547982

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