TNF and type I IFN induction of the IRG1-itaconate pathway restricts Coxiella burnetii replication within mouse macrophages

The intracellular Gram-negative bacterium Coxiella burnetii replicates within macrophages and causes a zoonotic disease known as Q fever. In murine macrophages, the cytokine tumor necrosis factor (TNF) is critical for restriction of intracellular C. burnetii replication. Here, we show that TNF colla...

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Detalles Bibliográficos
Autores principales: Boyer, Mark A., Fischer, Natasha Lopes, Shin, Sunny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350068/
https://www.ncbi.nlm.nih.gov/pubmed/37461589
http://dx.doi.org/10.1101/2023.07.07.548079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350068/
https://www.ncbi.nlm.nih.gov/pubmed/37461589
http://dx.doi.org/10.1101/2023.07.07.548079

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