Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice

Nonalcoholic steatohepatitis (NASH) is a malady of multiple cell types associated with hepatocyte triglyceride (TG) accumulation, macrophage inflammation, and stellate cell-induced fibrosis, with no approved therapeutics yet available. Here, we report that stellate cell fatty acid synthase (FASN) in...

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Detalles Bibliográficos
Autores principales: Yenilmez, Batuhan, Harney, Shauna, DiMarzio, Chloe, Kelly, Mark, Min, Kyounghee, Echeverria, Dimas, Bramato, Brianna M., Jackson, Samuel O., Reddig, Keith, Kim, Jason K., Khvorova, Anastasia, Czech, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350091/
https://www.ncbi.nlm.nih.gov/pubmed/37461560
http://dx.doi.org/10.1101/2023.07.05.547848

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350091/
https://www.ncbi.nlm.nih.gov/pubmed/37461560
http://dx.doi.org/10.1101/2023.07.05.547848

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