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Dual targeting of hepatocyte DGAT2 and stellate cell FASN alleviates nonalcoholic steatohepatitis in mice
Nonalcoholic steatohepatitis (NASH) is a malady of multiple cell types associated with hepatocyte triglyceride (TG) accumulation, macrophage inflammation, and stellate cell-induced fibrosis, with no approved therapeutics yet available. Here, we report that stellate cell fatty acid synthase (FASN) in...
Autores principales: | Yenilmez, Batuhan, Harney, Shauna, DiMarzio, Chloe, Kelly, Mark, Min, Kyounghee, Echeverria, Dimas, Bramato, Brianna M., Jackson, Samuel O., Reddig, Keith, Kim, Jason K., Khvorova, Anastasia, Czech, Michael P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350091/ https://www.ncbi.nlm.nih.gov/pubmed/37461560 http://dx.doi.org/10.1101/2023.07.05.547848 |
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