Mechanism of DNA unwinding by hexameric MCM8–9 in complex with HROB

The human MCM8–9 helicase functions in concert with HROB in the context of homologous recombination, but its precise function is unknown. To gain insights into how HROB regulates MCM8–9, we first used molecular modeling and biochemistry to define their interaction interface. We show that HROB makes...

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Detalles Bibliográficos
Autores principales: Acharya, Ananya, Bret, Hélène, Huang, Jen-Wei, Mütze, Martin, Göse, Martin, Kissling, Vera, Seidel, Ralf, Ciccia, Alberto, Guérois, Raphaël, Cejka, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350107/
https://www.ncbi.nlm.nih.gov/pubmed/37461676
http://dx.doi.org/10.21203/rs.3.rs-3054483/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350107/
https://www.ncbi.nlm.nih.gov/pubmed/37461676
http://dx.doi.org/10.21203/rs.3.rs-3054483/v1

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