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Mechanism of DNA unwinding by hexameric MCM8–9 in complex with HROB
The human MCM8–9 helicase functions in concert with HROB in the context of homologous recombination, but its precise function is unknown. To gain insights into how HROB regulates MCM8–9, we first used molecular modeling and biochemistry to define their interaction interface. We show that HROB makes...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350107/ https://www.ncbi.nlm.nih.gov/pubmed/37461676 http://dx.doi.org/10.21203/rs.3.rs-3054483/v1 |