Cargando…

Broad Protection Against Clade 1 Sarbecoviruses After a Single Immunization with Cocktail Spike-Protein-Nanoparticle Vaccine

The 2002 SARS outbreak, the 2019 emergence of COVID-19, and the continuing evolution of immune-evading SARS-CoV-2 variants together highlight the need for a broadly protective vaccine against ACE2-utilizing sarbecoviruses. While updated variant-matched formulations such as Pfizer-BioNTech’s bivalent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Halfmann, Peter J., Loeffler, Kathryn, Duffy, Augustine, Kuroda, Makoto, Kawaoka, Yoshihiro, Kane, Ravi S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350183/ https://www.ncbi.nlm.nih.gov/pubmed/37461652 http://dx.doi.org/10.21203/rs.3.rs-3088907/v1

Ejemplares similares

Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus
por: Lee, Jimin, et al.
Publicado: (2023)

Multivalent S2-based vaccines provide broad protection against SARS-CoV-2 variants of concern and pangolin coronaviruses
por: Halfmann, Peter J., et al.
Publicado: (2022)

Rational identification of potent and broad sarbecovirus-neutralizing antibody cocktails from SARS convalescents
por: Cao, Yunlong, et al.
Publicado: (2022)

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
por: Walls, Alexandra C., et al.
Publicado: (2021)

Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines
por: Walls, Alexandra C., et al.
Publicado: (2021)

Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization
por: Chiba, Shiho, et al.
Publicado: (2021)

Isolation of Bat Sarbecoviruses, Japan
por: Murakami, Shin, et al.
Publicado: (2022)

Potent neutralization of SARS‐CoV‐2 including variants of concern by vaccines presenting the receptor‐binding domain multivalently from nanoscaffolds
por: Halfmann, Peter J., et al.
Publicado: (2021)

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
por: Martinez, David R., et al.
Publicado: (2021)

Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice
por: Martinez, David R., et al.
Publicado: (2021)

Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses
por: Mao, Tianyang, et al.
Publicado: (2022)

HER2-mediated enhancement of Ebola virus entry
por: Kuroda, Makoto, et al.
Publicado: (2020)

Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses
por: Brinkkemper, Mitch, et al.
Publicado: (2022)

Broad sarbecovirus neutralizing antibodies define a key site of vulnerability on the SARS-CoV-2 spike protein
por: Wec, Anna Z., et al.
Publicado: (2020)

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody
por: Tortorici, M. Alejandra, et al.
Publicado: (2021)

Mosaic RBD nanoparticles protect against multiple sarbecovirus challenges in animal models
por: Cohen, Alexander A., et al.
Publicado: (2022)

Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
por: Cohen, Alexander A., et al.
Publicado: (2022)

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
por: Park, Young-Jun, et al.
Publicado: (2021)

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses
por: Liu, Lihong, et al.
Publicado: (2022)

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry
por: Park, Young-Jun, et al.
Publicado: (2022)

A broadly neutralizing nanobody targeting the highly conserved S2 subunit of sarbecoviruses
por: Wang, Xiaoyun, et al.
Publicado: (2023)

Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening
por: Yang, Xuehua, et al.
Publicado: (2023)

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants
por: Changrob, Siriruk, et al.
Publicado: (2023)

Humoral responses to the SARS-CoV-2 spike and receptor binding domain in context of pre-existing immunity confer broad sarbecovirus neutralization
por: Hauser, Blake M., et al.
Publicado: (2022)

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
por: Hurlburt, Nicholas K., et al.
Publicado: (2022)

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2
por: Ma, Yong, et al.
Publicado: (2023)

Pan-sarbecovirus mAb protects from variants
por: Flemming, Alexandra
Publicado: (2021)

Characterization of highly pathogenic clade 2.3.4.4b H5N1 mink influenza viruses
por: Maemura, Tadashi, et al.
Publicado: (2023)

The Glycan-Binding Trait of the Sarbecovirus Spike N-Terminal Domain Reveals an Evolutionary Footprint
por: Guo, Hua, et al.
Publicado: (2022)

Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity
por: Chen, Wei-Hung, et al.
Publicado: (2023)

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies
por: Jette, Claudia A., et al.
Publicado: (2021)

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies
por: Jette, Claudia A., et al.
Publicado: (2021)

Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies
por: Jette, Claudia A., et al.
Publicado: (2021)

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice
por: Martinez, David R., et al.
Publicado: (2023)

Antibody-Dependent Enhancement of SARS-CoV-2 Infection Is Mediated by the IgG Receptors FcγRIIA and FcγRIIIA but Does Not Contribute to Aberrant Cytokine Production by Macrophages
por: Maemura, Tadashi, et al.
Publicado: (2021)

Superimmunity by pan-sarbecovirus nanobodies
por: Xiang, Yufei, et al.
Publicado: (2022)

Structural basis for the broad and potent cross-reactivity of an N501Y-centric antibody against sarbecoviruses
por: Jeong, Bo-Seong, et al.
Publicado: (2022)

Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes
por: Fan, Chengcheng, et al.
Publicado: (2022)

Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination
por: Adams, Lily E., et al.
Publicado: (2023)

Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity
por: Jensen, Jaime L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lb21120jdpeenhqv19isrmvrvo