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STAT1 is required to establish but not maintain interferon‐γ‐induced transcriptional memory

Exposure of human cells to interferon‐γ (IFNγ) results in a mitotically heritable yet reversible state called long‐term transcriptional memory. We previously identified the clustered GBP genes as strongly primed by IFNγ. Here, we discovered that in primed cells, both interferon‐responsive transcript...

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Detalles Bibliográficos
Autores principales: Tehrani, Sahar SH, Mikulski, Pawel, Abdul‐Zani, Izma, Mata, João F, Siwek, Wojciech, Jansen, Lars ET
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350821/
https://www.ncbi.nlm.nih.gov/pubmed/37272165
http://dx.doi.org/10.15252/embj.2022112259