Synthesis of a Novel Boronic Acid Transition State Inhibitor, MB076: A Heterocyclic Triazole Effectively Inhibits Acinetobacter-Derived Cephalosporinase Variants with an Expanded-Substrate Spectrum

[Image: see text] Class C Acinetobacter-derived cephalosporinases (ADCs) represent an important target for inhibition in the multidrug-resistant pathogen Acinetobacter baumannii. Many ADC variants have emerged, and characterization of their structural and functional differences is essential. Equally...

Descripción completa

Detalles Bibliográficos
Autores principales: Powers, Rachel A., June, Cynthia M., Fernando, Micah C., Fish, Erin R., Maurer, Olivia L., Baumann, Rachelle M., Beardsley, Trevor J., Taracila, Magdalena A., Rudin, Susan D., Hujer, Kristine M., Hujer, Andrea M., Santi, Nicolò, Villamil, Valentina, Introvigne, Maria Luisa, Prati, Fabio, Caselli, Emilia, Bonomo, Robert A., Wallar, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350917/
https://www.ncbi.nlm.nih.gov/pubmed/37358467
http://dx.doi.org/10.1021/acs.jmedchem.3c00144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350917/
https://www.ncbi.nlm.nih.gov/pubmed/37358467
http://dx.doi.org/10.1021/acs.jmedchem.3c00144

Ejemplares similares