Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor

[Image: see text] Recent clinical reports have highlighted the need for wild-type (WT) and mutant dual inhibitors of c-MET kinase for the treatment of cancer. We report herein a novel chemical series of ATP competitive type-III inhibitors of WT and D1228V mutant c-MET. Using a combination of structu...

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Detalles Bibliográficos
Autores principales: Michaelides, Iacovos N., Collie, Gavin W., Börjesson, Ulf, Vasalou, Christina, Alkhatib, Omar, Barlind, Louise, Cheung, Tony, Dale, Ian L., Embrey, Kevin J., Hennessy, Edward J., Khurana, Puneet, Koh, Cheryl M., Lamb, Michelle L., Liu, Jianming, Moss, Thomas A., O’Neill, Daniel J., Phillips, Christopher, Shaw, Joseph, Snijder, Arjan, Storer, R. Ian, Stubbs, Christopher J., Han, Fujin, Li, Chengzhi, Qiao, Jingchuan, Sun, Dong-Qing, Wang, Jingwen, Wang, Peng, Yang, Wenzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350928/
https://www.ncbi.nlm.nih.gov/pubmed/37343272
http://dx.doi.org/10.1021/acs.jmedchem.3c00401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10350928/
https://www.ncbi.nlm.nih.gov/pubmed/37343272
http://dx.doi.org/10.1021/acs.jmedchem.3c00401

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