Cargando…

Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia

Siglec-15 (Sig15) has been implicated as an immune checkpoint expressed in solid tumor-infiltrating macrophages and is being targeted in clinical trials with mAbs to normalize the tumor immune microenvironment and stimulate antitumor immunity. However, the role of Sig15 in hematologic malignancies r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pillsbury, Claire E., Dougan, Jodi, Rabe, Jennifer L., Fonseca, Jairo A., Zhou, Chengjing, Evans, Alyssa N., Abukharma, Hasan, Ichoku, Ona, Gonzalez-Flamenco, Gloria, Park, Sunita I., Aljudi, Ahmed, DeRyckere, Deborah, Castellino, Sharon M., Rafiq, Sarwish, Langermann, Solomon, Liu, Linda N., Henry, Curtis J., Porter, Christopher C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351425/ https://www.ncbi.nlm.nih.gov/pubmed/37465593 http://dx.doi.org/10.1158/2767-9764.CRC-23-0056

Ejemplares similares

Association of race/ethnicity with innate immune tumor microenvironment of children with B-acute lymphoblastic leukemia
por: Gilbert, Julie R, et al.
Publicado: (2022)

Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis
por: Bhasin, Swati S., et al.
Publicado: (2023)

Development of an Immunohistochemical Assay for Siglec-15
por: Shafi, Saba, et al.
Publicado: (2022)

Inhibition of MerTK increases chemosensitivity and decreases oncogenic potential in T-cell acute lymphoblastic leukemia
por: Brandao, L N, et al.
Publicado: (2013)

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
por: Wang, Jun, et al.
Publicado: (2019)

Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia
por: Pastorczak, Agata, et al.
Publicado: (2021)

The Current State of FLT3 Inhibition in Acute Myeloid Leukemia – Pitfalls and Promises
por: Minson, Katherine A, et al.
Publicado: (2017)

Siglec Ligands
por: Gonzalez-Gil, Anabel, et al.
Publicado: (2021)

Molecular cloning of porcine Siglec-3, Siglec-5 and Siglec-10, and identification of Siglec-10 as an alternative receptor for porcine reproductive and respiratory syndrome virus (PRRSV)
por: Xie, Jiexiong, et al.
Publicado: (2017)

Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer
por: Yan, Dan, et al.
Publicado: (2021)

Engineering strategies to overcome the current roadblocks in CAR T cell therapy
por: Rafiq, Sarwish, et al.
Publicado: (2019)

Coevolution of Siglec-11 and Siglec-16 via gene conversion in primates
por: Hayakawa, Toshiyuki, et al.
Publicado: (2017)

Mechanisms of Immunosuppressive Tumor Evasion: Focus on Acute Lymphoblastic Leukemia
por: Jiménez-Morales, Silvia, et al.
Publicado: (2021)

Therapeutic Targeting of MERTK and BCL-2 in T-Cell and Early T-Precursor Acute Lymphoblastic Leukemia
por: Summers, Ryan J., et al.
Publicado: (2022)

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
por: Rodriguez, Ernesto, et al.
Publicado: (2021)

B-cell acute lymphoblastic leukemia promotes an immune suppressive microenvironment that can be overcome by IL-12
por: Hunter, Rae, et al.
Publicado: (2022)

The Emerging Role of TYRO3 as a Therapeutic Target in Cancer
por: Smart, Sherri K., et al.
Publicado: (2018)

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia
por: Lee, Miyoung, et al.
Publicado: (2022)

Siglecs at the Host–Pathogen Interface
por: Chang, Yung-Chi, et al.
Publicado: (2020)

Siglecs as Therapeutic Targets in Cancer
por: Lim, Jackwee, et al.
Publicado: (2021)

Siglec Signaling in the Tumor Microenvironment
por: van Houtum, Eline J. H., et al.
Publicado: (2021)

The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression
por: Zheng, Yayun, et al.
Publicado: (2020)

Targeting the TAM Receptors in Leukemia
por: Huey, Madeline G., et al.
Publicado: (2016)

Bioluminescence imaging of leukemia cell lines in vitro and in mouse xenografts: effects of monoclonal and polyclonal cell populations on intensity and kinetics of photon emission
por: Christoph, Sandra, et al.
Publicado: (2013)

Siglecs in Brain Function and Neurological Disorders
por: Siddiqui, Shoib Sarwar, et al.
Publicado: (2019)

Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14
por: Murch, Simon H.
Publicado: (2020)

Machine learning classifier approaches for predicting response to RTK-type-III inhibitors demonstrate high accuracy using transcriptomic signatures and ex vivo data
por: Ferrato, Mauricio H, et al.
Publicado: (2023)

Multipurposing CARs: Same engine, different vehicles
por: Hossian, A.K.M. Nawshad, et al.
Publicado: (2022)

Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus
por: Ali, Syed Raza, et al.
Publicado: (2014)

Comparison of (68)Ga-DOTA-Siglec-9 and (18)F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry
por: Virtanen, Helena, et al.
Publicado: (2017)

Ablation of Siglec-E augments brain inflammation and ischemic injury
por: Li, Lexiao, et al.
Publicado: (2022)

Role of Siglec-7 in Apoptosis in Human Platelets
por: Nguyen, Kim Anh, et al.
Publicado: (2014)

Normalization cancer immunotherapy: blocking Siglec-15!
por: Cao, Guangchao, et al.
Publicado: (2019)

Discovery, Function, and Therapeutic Targeting of Siglec-8
por: Youngblood, Bradford A., et al.
Publicado: (2020)

The Role of Siglec-G on Immune Cells in Sepsis
por: Royster, William, et al.
Publicado: (2021)

CD24-Siglec interactions in inflammatory diseases
por: Liu, Yang, et al.
Publicado: (2023)

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9
por: Chan, Chilam, et al.
Publicado: (2023)

Siglec receptors impact mammalian lifespan by modulating oxidative stress
por: Schwarz, Flavio, et al.
Publicado: (2015)

Single-cell RNA sequencing distinctly characterizes the wide heterogeneity in pediatric mixed phenotype acute leukemia
por: Mumme, Hope L., et al.
Publicado: (2023)

Prolonged Exposure to a Mer Ligand in Leukemia: Gas6 Favors Expression of a Partial Mer Glycoform and Reveals a Novel Role for Mer in the Nucleus
por: Migdall-Wilson, Justine, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_v04kt6l8nb768jsj6d8tdv284r