Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease

Impaired activities and abnormally enlarged structures of endolysosomes are frequently observed in Alzheimer disease (AD) brains. However, little is known about whether and how endolysosomal dysregulation is triggered and associated with AD. Here, we show that vacuolar ATPase (V-ATPase) is a hub tha...

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Detalles Bibliográficos
Autores principales: Kim, Seo-Hyun, Cho, Young-Sin, Kim, Youbin, Park, Jisu, Yoo, Seung-Min, Gwak, Jimin, Kim, Youngwon, Gwon, Youngdae, Kam, Tae-in, Jung, Yong-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351450/
https://www.ncbi.nlm.nih.gov/pubmed/36843263
http://dx.doi.org/10.1080/15548627.2023.2181614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10351450/
https://www.ncbi.nlm.nih.gov/pubmed/36843263
http://dx.doi.org/10.1080/15548627.2023.2181614

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